بررسی پدیده original antigenic sin و وجود ارتباط بین موشهای مختلف ویروسهای آنفلوآنزای تیپ a
پایان نامه
- وزارت علوم، تحقیقات و فناوری - دانشگاه تهران
- نویسنده ثریا منتظری
- استاد راهنما منیژه خاکپور
- تعداد صفحات: ۱۵ صفحه ی اول
- سال انتشار 1357
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منابع مشابه
Overcoming original (antigenic) sin.
Original antigenic sin describes a phenomenon in which the antibody response elicited in an individual after a secondary viral infection reacts more strongly to the viral variant that originally infected the individual. As T helper cells play critical roles in promoting antibody responses, a similar phenomenon may hold true for T helper cell responses. This concept is particularly relevant to t...
متن کاملDisquisitions on Original Antigenic Sin
Experiments in rabbits were designed to test the two unproven assumptions of the hypothesis proposed in the companion paper (1): that Original Antigenic Sin is fundamentally a restricted anamnestic response, and that there exists a trapping mechanism capable of deflecting antigen from one kind of cell and guiding it to another. It is shown that whole-body X-irradiation, sufficient to abolish pr...
متن کاملOriginal antigenic sin in dengue revisited.
The four dengue virus serotypes (DENV-1 to -4) cause the most important arthropod-borne viral disease of humans, with ∼100 million cases each year and over 3 billion people at risk for infection (1). The immune response to DENV infection is complex, because it can be either protective or pathogenic. The “original antigenic sin” in secondary (2°) DENV infections is defined as the dominance of cr...
متن کاملOriginal Antigenic Sin and Pandemic (H1N1) 2009
To the Editor: While pandemic (H1N1) 2009 was in its earliest stages, age distribution data indicated surprisingly few cases among persons >65 years of age. The initial assumption was that few persons >65 years of age had yet to be exposed. However, as more data became available from Mexico, Australia, and the United States, the age distribution pattern persisted (1). This observation raised th...
متن کاملThe Wages of Original Antigenic Sin
was thinking when pondering certain inexplicable serologic data from a 1946 infl uenza vaccine trial may never be known. Whether in religious reverence for the beauty of science or impish delight fueled by the martini breaks of which he was so fond, Francis coined the term " original antigenic sin " to describe a curious new immunologic phenomenon. Elsewhere in this issue, Adalja and Henderson ...
متن کاملOriginal antigenic sin responses to influenza viruses.
Most immune responses follow Burnet's rule in that Ag recruits specific lymphocytes from a large repertoire and induces them to proliferate and differentiate into effector cells. However, the phenomenon of "original antigenic sin" stands out as a paradox to Burnet's rule of B cell engagement. Humans, upon infection with a novel influenza strain, produce Abs against older viral strains at the ex...
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وزارت علوم، تحقیقات و فناوری - دانشگاه تهران
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